Chicken Bubble Biscuit Bake Casserole

If you’re craving a warm, family-friendly meal that’s easy to make and full of creamy, cheesy comfort, this Chicken Bubble Biscuit Bake Casserole is the answer. It’s the kind of dish that turns a busy weeknight into something special with minimal effort. Tender pieces of chicken, soft buttery biscuits, and a creamy sauce come together in a single baking dish that’s as satisfying as it is simple. I love how versatile it is—you can toss in extra vegetables, swap cheeses, or even use leftover rotisserie chicken. When I made this for my family, the golden, bubbly top got rave reviews. It’s the ultimate comfort food: hearty, cozy, and always a crowd-pleaser.

Why You’ll Love This Recipe

This casserole combines convenience and comfort in every bite. It’s made with just a handful of pantry staples, yet delivers the rich, homemade flavor of a traditional chicken pot pie. The “bubble-up” effect of the biscuits creates a beautifully golden crust that perfectly contrasts the creamy filling underneath. Plus, it’s quick to prepare and family-approved, making it a go-to for busy evenings.

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Ingredients

(Tip: You can find the complete list of ingredients and their measurements in the recipe card below.)

Cooked chicken – Shredded or cubed chicken provides the heartiness of this casserole. Rotisserie chicken works perfectly if you’re short on time.

Refrigerated biscuit dough – The “bubble” element of the dish! As the biscuits bake, they puff up beautifully, creating a light, golden crust.

Cream of chicken soup – This forms the creamy base of the casserole. It adds richness and helps bind everything together.

Sour cream – Adds a tangy depth that balances the richness of the sauce. It also keeps the filling extra creamy.

Cheddar cheese – Sharp cheddar melts perfectly over the top, giving that irresistible gooey finish. You can mix in mozzarella or Monterey Jack for a twist.

Mixed vegetables – Frozen peas, carrots, and corn add color, flavor, and nutrition. They also make the dish more filling.

Garlic powder – Enhances the flavor and gives the casserole a delicious savory note.

Salt and black pepper – Essential for seasoning, bringing out the full flavor of the ingredients.

Butter – Brushed over the top for extra flavor and a glossy, golden finish.

Directions

Preheat the oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish. In a large mixing bowl, combine the cream of chicken soup, sour cream, garlic powder, salt, and pepper. Stir in the cooked chicken and mixed vegetables until evenly coated. Cut the refrigerated biscuits into quarters and gently fold them into the mixture, making sure each piece is coated with sauce. Pour the mixture into the prepared baking dish and spread evenly. Sprinkle the shredded cheddar cheese over the top. Bake for 25–30 minutes or until the biscuits have puffed up and the top is golden brown. Brush the surface lightly with melted butter for extra flavor. Let the casserole rest for about 5 minutes before serving—it will thicken slightly as it cools.

Equipment needed :

Must-Have Tools to Get Rolling

Here’s what you’ll want to have on hand:

Silicone Spatula – Durable, heat-resistant silicone spatula perfect for mixing, scraping, and spreading. Gentle on non-stick cookware and easy to clean.

Large pot – You’ll need this to boil the whole cabbage head and soften the leaves.

large bowl –Spacious, durable large bowl ideal for mixing, serving, or food preparation. Made from sturdy material and easy to clean.

Sharp knife – For coring the cabbage and slicing out the thick stem in each leaf. A paring knife works best.

Mixing bowl – A big bowl makes it easier to combine your meat and rice filling evenly.

Cutting board – For prepping cabbage leaves and rolling them like a pro.

9×13-inch baking dish – Ideal size to fit your rolled cabbage leaves snugly and prevent them from unraveling.

knife – A sharp, durable kitchen knife perfect for slicing, chopping, and dicing with ease.

Servings and timing

This recipe makes 6 generous servings. Preparation takes about 15 minutes, baking about 30 minutes, and cooling around 5 minutes.

Storage/reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, cover with foil and warm in the oven at 325°F for 10–12 minutes. You can also reheat individual portions in the microwave for 1–2 minutes.

Variations and Customizations

Buffalo Chicken Bubble Bake – Add buffalo sauce and blue cheese for a spicy kick.
Broccoli Cheddar Version – Mix in steamed broccoli and extra cheddar for a veggie-packed twist.
Ranch Chicken Casserole – Stir in a packet of ranch seasoning for a tangy, herby flavor.
Bacon Lover’s Edition – Sprinkle cooked bacon bits over the top before baking for added crunch.
Tex-Mex Style – Add black beans, corn, and taco seasoning, and top with pepper jack cheese.
Mushroom Cream Bake – Replace cream of chicken with cream of mushroom soup for a deeper, earthy flavor.
Italian-Inspired Bake – Use mozzarella, Italian seasoning, and a touch of marinara for a pizza-like casserole.
Vegetarian Swap – Substitute chicken with sautéed mushrooms and extra vegetables for a hearty meat-free version.
Extra-Cheesy Delight – Combine two or three cheeses—cheddar, gouda, and Monterey Jack for rich layers of flavor.
Healthier Twist – Use reduced-fat sour cream, light cheese, and whole-grain biscuits for a lighter meal.

FAQs

Can I use canned chicken instead of cooked chicken?

Yes, canned chicken works fine—just drain it well before mixing.

Can I make this casserole ahead of time?

Yes, assemble it and refrigerate up to 12 hours before baking.

How do I keep the biscuits from getting soggy?

Make sure to bake until the biscuits are fully golden and puffed.

Can I freeze the casserole?

Yes, freeze it after baking and cooling completely for up to 2 months.

Can I use homemade biscuits?

Absolutely—just cut them into small pieces before mixing them in.

Can I add extra vegetables?

Yes, feel free to add mushrooms, spinach, or chopped bell peppers.

What kind of cheese works best?

Sharp cheddar is classic, but a blend of cheddar and mozzarella melts beautifully.

Can I double the recipe?

Yes, simply use a larger baking dish and adjust the baking time by 10–15 minutes.

What can I serve with it?

A green salad or steamed vegetables make perfect sides.

How do I know it’s done?

The biscuits should be golden brown and the sauce bubbling around the edges.

Conclusion

This Chicken Bubble Biscuit Bake Casserole is a true comfort classic—rich, creamy, and satisfying. It’s the perfect way to transform simple ingredients into a hearty meal that everyone will love. Whether you’re feeding a family or hosting guests, this bubbly, golden casserole will have everyone coming back for seconds. Warm, cheesy, and easy to make, it’s the ultimate cozy dinner for any night of the week.

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